Cellefill and Flexfill isolator solutions

Protect aseptic processes while accelerating qualification, validation and time to production with  modular isolator-based filling and containment solutions.

Picture of an isolator.

Modular isolator solutions for aseptic fill and finish.

Based on PROLine isolators, Cellefill and Flexfill are different partner projects that combine containment, filling, and modular design to support aseptic processing of syringes, vials, and cartridges with integrated protection and validation readiness.

Benefits

Flexfill

Faster time to patient requirements 

The modular design of Flexfill allows for 80% pre-defined configuration, which leads to faster deployment, commissioning, and shortened production start-up times.

One coordinated partner solution

Pre-configured and pre-qualified systems help reduce implementation time and cost, while one point of contact and a coordinated team simplify project delivery.

Customization through pre-configured modules

Choose from pre-configured modules to customize your system for filling syringes, vials, and cartridges according to your production needs.

Optimized for your applications

Our solutions were designed with different approaches to meet different requirements.

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Flexfill: standardized filling with modular flexibility

Filling and closing machine with isolator for ready-to-use syringes, vials and cartridges.

Flexfill is a filling and closing system for ready-to-use syringes, vials, and cartridges. It was designed to be safe, flexible, and easy to adapt to different production needs. 

The system uses a modular design, with up to 80% pre-configured components. This setup allows for faster installation and start-up, helping you begin production sooner and meet regulatory requirements more easily. 

Flexfill was developed through close collaboration between groninger and Franz Ziel, providing a well-coordinated solution from a single source and meeting all GMP standards. 

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Cellefill: integrated vial filling for smaller batch production

Vial filling machine and containment solution to fast track your cell, gene and biological therapies. 

Cellefill is a turnkey vial filling machine with integrated containment designed for cell, gene, and biological therapies. 

It was designed to be easy to run, helping you produce consistently high-quality batches. Its recipe-based operation simplifies use and supports faster production and time to market, which makes it an ideal solution for treatments like cell and gene therapies. Thanks to its peristaltic pump, the system also improves batch safety with accurate filling and built-in environmental monitoring. 

Cellefill is GMP-compliant and was developed by Flexicon Liquid Filling and Franz Ziel, combining expertise in filling and containment into one solution. 

Modular design and integrated isolator technology

Flexfill, Cellefill and other partner projects combine modular design with integrated isolator technology to ensure different aseptic fill and finish processes. 

By bringing together containment, automation, and configurable system architecture, both solutions enable controlled environments, efficient deployment, and streamlined validation. 

Franz Ziel - Product Protection Isolator

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Features & Capabilities

Explore the main features of the Cellefill and Flexfill solutions:

Related solutions

Explore other aseptic processing solutions.

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PPI

The Personal Product Isolator provides targeted product protection in aseptic processes with unidirectional laminar airflow.

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PROLine

PROLine provides high-performance, customized isolator systems designed for aseptic processes, such as filling and freeze-dryer loading and unloading.

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PROcLine

A GMP-compliant isolator system for highly potent and toxic pharmaceuticals, delivering validated aseptic containment for safe product and operator protection.

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FLI

The FLI is a flexibly configurable isolator providing Grade A product protection and optional operator protection.

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STI

The STI isolator enables sterility testing under advanced aseptic conditions, with optional containment for toxic substances.

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cRABS

The closed Restricted Access Barrier System serves as a specialized housing for aseptic processes, specifically for the filling, loading, and unloading of freeze dryers.

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oRABS

The open Restricted Access Barrier System is designed to support compliant aseptic processing by creating a controlled barrier between operator and product.

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Get in touch

Speak to our specialists about our range of flexible, scalable, end-to-end solutions—tailored to you.